Polynucleotides at a Glance
- Treatment Goal: Skin regeneration, improved skin quality, and reduction of dark circles under the eyes
- Treatment Areas: Under-eye area, face, neck, décolletage, hands
- Mode of Action: Biostimulation through purified DNA fragments to support cell renewal and collagen synthesis
- Treatment Duration: Approximately 20–30 minutes
- Social Downtime: Typically none
- Longevity: Around 6 months, depending on skin condition and individual response
- Recommended Sessions: 2–3 treatments spaced 3–4 weeks apart
- Side Effects: Mild swelling, redness, or small bruises may occur
- Can Be Combined With: Hyaluronic acid filler treatments, skin boosters, or microneedling
- Results: Fresher, smoother, and more elastic skin with a naturally radiant glow
- Cost: From approx. €320 (guide price, billed according to the German Medical Fee Schedule – GOÄ)
Table of Contents:
- What Are Polynucleotides?
- Effects and Benefits of Polynucleotides
- Treatment of Dark Circles and Other Areas
- Treatment Procedure
- Results and Longevity
- Risks and Possible Side Effects
- Cost of a Polynucleotide Treatment
- Why Choose Dr. Eva Maria Strobl for Polynucleotides in Munich
- FAQ – Polynucleotide Treatment in Munich
What Are Polynucleotides?
Biologically Active DNA Fragments
Polynucleotides are biologically active DNA fragments that stimulate the body’s natural cell regeneration and skin renewal. They act as biostimulators that improve microcirculation, reduce inflammation, and deeply hydrate the skin. Unlike hyaluronic acid fillers, polynucleotides do not create volume but instead activate the skin’s own repair and regeneration processes.
These properties make them ideal for delicate areas such as the under-eye region, as well as the face, neck, décolletage, and hands. The result is smoother, more elastic, and revitalized skin that radiates from within.
Extraction and Biocompatibility
Injectable polynucleotides are typically derived from salmon sperm, which contains a particularly high concentration of DNA. This source provides excellent biocompatibility, as the structure of salmon DNA closely resembles that of humans. In the United States, treatments with polynucleotides are therefore often referred to as the “Salmon Sperm Facial.”
Through a multi-step purification process, the DNA strands are isolated, purified, and broken down into smaller biologically active fragments suitable for medical use. The result is highly purified polynucleotides that are safe, well tolerated, and low in allergens.
What Does PDRN Mean?
he abbreviation PDRN stands for Polydeoxyribonucleotide, a specific form of polynucleotide. PDRN consists of DNA fragments that actively promote cell regeneration, wound healing, and tissue repair.
In aesthetic medicine, PDRN and polynucleotides are often used interchangeably, as both support the skin’s biological renewal and lead to visible improvements in texture, hydration, and elasticity.
Effects and Benefits of Polynucleotides
Polynucleotides work on multiple levels of skin regeneration. They promote cell renewal, stimulate collagen and elastin production, and enhance microcirculation. As a result, the skin becomes smoother, more elastic, better hydrated, and visibly revitalized.
A key advantage lies in their biological mode of action: instead of creating volume like hyaluronic acid fillers, polynucleotides activate the skin’s natural self-repair mechanisms. The results develop gradually, appearing natural and harmonious.
Typical improvements after a polynucleotide treatment include:
- Reduction of dark circles and fine lines
- Smoother skin texture and improved elasticity
- A fresher, more radiant complexion through enhanced microcirculation
- Long-term skin quality improvement rather than short-term effects
- High safety and tolerability thanks to the natural DNA origin
Polynucleotides are suitable for revitalizing sensitive skin areas such as the under-eye region, face, neck, décolletage, and hands.
Treatment of Dark Circles and Other Areas
Polynucleotide Filler Croma PhilArt
In my Munich practice, I primarily use the injectable polynucleotide filler PhilArt by Croma. Croma PhilArt is an advanced medical-grade product with a high concentration of polynucleotides designed to actively enhance cell regeneration and skin quality.
Originally developed for the delicate under-eye area, it effectively targets dark circles, fine lines, and loss of hydration. In addition, PhilArt can be used for other areas such as the face, neck, décolletage, hands, and even the scalp in cases of diffuse hair thinning. In these regions, polynucleotides boost microcirculation and cell activity within the hair follicles, helping to stimulate hair growth and improve hair texture.
Treatment Areas
In my Munich practice, injectable polynucleotides are primarily used to treat the delicate skin around the eyes. They help smooth fine lines, reduce dark circles, and create firmer, more even skin.
Additional treatment areas include:
- Face: Improves skin texture and reduces fine lines
- Neck and Décolletage: Firms and boosts hydration
- Hands: Smooths and regenerates thin, aging skin
- Scalp: Supports hair regeneration in cases of hair loss or thinning
Polynucleotide treatments are minimally invasive, low risk, and take only a few minutes to perform..
Benefits of the Treatment
- Skin Regeneration: Polynucleotides activate cell renewal and support the skin’s natural ability to repair and regenerate itself. They stimulate the body’s own healing mechanisms, contributing to long-lasting, healthy, and youthful skin structure.
- Improved Skin Texture: By stimulating collagen and elastin production, the skin becomes firmer, smoother, and more even. Fine lines, wrinkles, and uneven texture visibly improve—especially around the eyes and cheeks, where the skin is particularly thin.
- Support for Hair Growth: Polynucleotides enhance microcirculation and cell activity in the scalp, improving the nourishment of hair follicles. This can increase hair density and quality while helping to slow early stages of hair thinning.
Treatment Procedure
- Consultation and Analysis: A personalized assessment of the skin or scalp condition, discussion of treatment goals, and selection of the most suitable polynucleotide product.
- Cleansing and Preparation: Thorough skin cleansing followed by the application of a topical numbing cream if needed to minimize injection discomfort.
- Injection: Precise microinjections of polynucleotides using a fine needle or cannula into the targeted areas such as the under-eye region, face, neck, or scalp.
- Aftercare: Cooling of the treated area and application of a soothing cream. Post-treatment care instructions, including skin and sun protection, are discussed.
- Regeneration Phase: Initial improvements are usually visible after a few days, with optimal results achieved after 2–3 sessions spaced about 3–4 weeks apart.
Results and Longevity
- Sichtbare Hautverbesserung bereits nach wenigen Tagen, mit zunehmender Wirkung über mehrere Wochen hinweg.
- Hautbild wirkt frischer, glatter und elastischer, besonders in der empfindlichen Augenregion.
- Langzeiteffekt durch Aktivierung der körpereigenen Kollagen- und Elastinproduktion.
- Haltbarkeit der Ergebnisse in der Regel 6 bis 9 Monate, abhängig von Hautzustand, Stoffwechsel und Lebensstil.
- Auffrischungsbehandlungen alle 6 Monate empfohlen, um das Ergebnis langfristig zu stabilisieren und die Hautqualität kontinuierlich zu verbessern.
Risks and Possible Side Effects
Polynucleotides are generally very well tolerated, as they are derived from purified, biocompatible DNA with minimal allergenic potential. However, as with any injectable treatment, temporary reactions may occur:
- Mild swelling or redness at the injection sites, usually subsiding within a few hours
- Small bruises or pinpoint hematomas, depending on individual skin sensitivity
- Temporary tightness or tenderness in the treated area
- Rare allergic reactions, for example to additives or disinfectants
- Very rare reactions in individuals with fish allergies, since the DNA is salmon-derived (risk is minimal due to purification)
- In exceptional cases, infection or vascular irritation may occur with improper injection technique
When performed by an experienced physician, the risk profile of polynucleotide treatments remains low, and the outcomes are predictable and satisfying.hrenen Arzt stellt sicher, dass das Risikoprofil der Behandlung mit Polynukleotiden moderat ausfällt und die Ergebnisse den Erwartungen entsprechen.
Cost of a Polynucleotide Treatment
Pricing for Polynucleotide Treatments
The cost of a polynucleotide treatment at my Munich practice starts at €320. The final price depends on the treatment area, the amount of product required, and the complexity of the individual case. Billing is carried out in accordance with the German Medical Fee Schedule (GOÄ).
Transparente Kosten
Before each treatment, a transparent cost estimate is provided so you know exactly what expenses to expect. There are no unexpected additional costs. Please note that aesthetic treatments with polynucleotides are not covered by statutory or private health insurance (GKV/PKV) and cannot be reimbursed.
Why Choose Dr. Eva Maria Strobl for Polynucleotides in Munich?
- Extensive experience from numerous successful treatments with polynucleotides and other regenerative procedures
- In-depth medical expertise specializing in minimally invasive skin rejuvenation and natural regenerative techniques
- All treatments performed exclusively by Dr. Eva Maria Strobl
- Ongoing training with leading experts in aesthetic medicine
- Use of the most advanced, evidence-based methods for maximum effectiveness and safety
- Strong focus on natural results by enhancing the body’s own regenerative capacity rather than artificial volume
- Centrally located practice in Munich, easily accessible by public transport, taxi, or car
- Transparent pricing and an excellent price-performance ratio
- Personal aftercare and direct accessibility via phone, email, or WhatsApp
- High patient satisfaction, confirmed by numerous positive reviews on Google, ProvenExpert, and Jameda
FAQ – Polynucleotide Treatment in Munich
Polynucleotides stimulate the skin’s natural regeneration, while hyaluronic acid fillers primarily restore volume. The result with polynucleotides is more subtle, yet biologically active and long-lasting.
Both treatments aim to rejuvenate the skin but differ in their mechanism of action. Profhilo is based on highly concentrated hyaluronic acid, which provides intense hydration and mild firming. Polynucleotides, on the other hand, stimulate cell regeneration and collagen production. Profhilo delivers faster results, while polynucleotides offer long-term structural improvement. In many cases, a combination of both yields optimal results.
Yes. Polynucleotides are highly biocompatible and especially suitable for thin, sensitive skin, such as the under-eye area.
Yes. Polynucleotides enhance microcirculation and cell activity in the scalp, supporting both hair growth and hair quality. At my Munich practice, I use a specialized polynucleotide formulation developed for the scalp, designed to stimulate hair follicles and improve scalp regeneration.ert.
About the Author:
Dr. med. univ. Eva Maria Strobl is the owner of LIPS and SKIN Aesthetic Medicine practice in Munich. She is a trained specialist in general medicine (MedUni Vienna) and has over 10 years of specialization in non-surgical aesthetic procedures. Dr. Strobl is a member of the German Society for Aesthetic Botulinum Therapy e.V. (DGBT), the German Society of Anti-Aging Medicine e.V. (GSAAM) and of Network Global Health. She publishes regularly on her blog and on DocCheck.
