Polynucleotides Under Eyes Treatment

Are Dark Circles Under Your Eyes Bothering You?

Discover How Polynucleotides Can Revitalize Your Eye Area!

Polynucleotides for the Eyes at a Glance

Polynucleotides are chains of DNA/RNA building blocks derived from salmon sperm, known for their regenerative properties.

In medicine, injectable polynucleotides support wound healing and skin regeneration. Cosmetically, they are used as skin boosters and fillers to improve skin texture and increase elasticity.

The treatment of the eye area with injectable polynucleotide fillers, such as Croma PhilArt, aims to smooth wrinkles, reduce dark circles, and tighten the skin around the eyes.

The treatment only takes a few minutes and is suitable for individuals showing signs of skin aging and dark circles under the eyes.

Possible side effects include redness, swelling, and, in rare cases, allergic reactions.

An eye treatment with injectable polynucleotides starts at 320€, based on standard rates and individual billing according to the GOÄ.

Polynucleotides – An Introduction

What Are Polynucleotides?

Polynucleotides are chains of nucleotides, the building blocks of DNA and RNA, playing a crucial role in many biological processes. They consist of long sequences of adenine, guanine, cytosine, and thymine—the four nucleotide bases of DNA—or adenine, guanine, cytosine, and uracil, the bases of RNA. These molecules are essential for cell function as they contain the genetic information necessary for the growth, development, and repair of cells and tissues. Hence, polynucleotides are often referred to as biostimulators or bioactivators.

How Are Polynucleotides Sourced?

Injectable polynucleotides are often derived from salmon sperm, offering high biological compatibility. Salmon sperm is a rich source of DNA, and the polynucleotides extracted from it are biologically active and compatible with human tissue. This method ensures that the polynucleotides are pure and effective, minimizing the risk of allergic reactions or rejections. The extraction process involves isolating and purifying the DNA, followed by fragmenting it into smaller, biologically active polynucleotides.

What Does PDRN Stand For?

PDRN stands for Polydeoxyribonucleotide. It is a specific type of polynucleotide composed of DNA fragments, typically sourced from salmon sperm. PDRN is well-known for its regenerative properties and is used in both medical and cosmetic applications to promote tissue repair and regeneration. In aesthetic medicine and cosmetics, the terms PDRN and polynucleotides are often used interchangeably.

What Are the Benefits of PDRN Treatment?

In medicine, PDRN is used for wound healing, skin regeneration, and the treatment of ischemia. Studies have shown that PDRN can accelerate the healing of chronic wounds and reduce scarring. It is also used in orthopedic medicine to aid the healing of bones and cartilage.

In cosmetics, PDRN is popular as a skin booster and filler. It improves skin texture, increases elasticity, and enhances collagen production. PDRN fillers are used to smooth wrinkles and fine lines, hydrate the skin, and achieve a more youthful appearance overall. Injectable polynucleotides are also effective in treating acne scars and hyperpigmentation.

I have been treating patients with polynucleotides in my practice in Munich for about two years. The most common application is the revitalization of age-related sagging eye areas and dark circles under the eyes.

Polynucleotides Under Eyes Treatment

Polynucleotide Filler Croma PhilArt

In my practice in Munich, I primarily work with the injectable polynucleotide filler PhilArt by Croma. Croma PhilArt is a highly effective filler specifically developed for the delicate skin around the eyes. It contains a high concentration of PDRN, which promotes cell regeneration and improves skin texture. Furthermore, Croma promises the highest quality standards in the manufacturing process, from monitoring the salmon farms to purifying the extracted DNA and processing it into a flawless and safe medical product.

Application Areas

I prefer to use injectable polynucleotides for treating the delicate skin around the eyes. They help smooth wrinkles, reduce dark circles, and tighten the skin. This treatment is particularly effective in improving skin elasticity and hydration, fostering a fresh and radiant appearance. The treatment is also straightforward and relatively low-risk. It takes just a few minutes.

Benefits of the Treatment

Skin Regeneration: Polynucleotides promote cell regeneration and help the skin renew itself. They are often referred to as biostimulators. The continuous renewal of cells ensures that the skin remains healthy and youthful. Polynucleotides stimulate the production of new skin cells and support the regeneration of damaged cells, leading to smoother and firmer skin.

Improvement of Skin Texture: The treatment results in a visible improvement in skin texture, increases elasticity, and provides a youthful appearance. By stimulating the production of collagen and elastin, the skin becomes denser and tighter. This reduces the appearance of fine lines and wrinkles and gives the skin a smooth, even texture. A firmer and denser skin also means that underlying blood vessels are less visible, significantly improving the appearance of dark circles under the eyes.

Reduction of Wrinkles: By stimulating collagen production, fine lines and wrinkles are reduced, leading to a smoother skin appearance. Polynucleotides help regenerate the skin from within, leading to a natural reduction of signs of aging. This makes them an ideal choice for individuals seeking a non-invasive method to reduce wrinkles in a sensitive facial area.

Hydration and Radiance: Polynucleotide injections improve skin moisture, contributing to a radiant and healthy complexion. Hydration is a crucial factor for healthy skin, as it strengthens the skin barrier and protects it from environmental stressors. Well-hydrated skin not only looks better but also feels more supple and elastic.

Who Are Polynucleotides Suitable For?

Possible Application Areas

Treatment with injectable polynucleotides is ideal for individuals looking to combat signs of skin aging, such as fine lines and wrinkles. It can also help with dark circles under the eyes and sagging skin. People seeking a non-invasive method to improve their skin appearance also benefit from this treatment. It is suitable for all skin types and age groups desiring a refresh and rejuvenation of the eye area.

Who Should Avoid the Treatment

Individuals with known allergies to components of the filler or with acute skin infections should avoid the treatment. Although the DNA from which the polynucleotides are derived is highly purified in a complex process, it is not guaranteed that traces of salmon protein might not remain. Therefore, individuals with a known fish allergy should verify the tolerance of the specific product before undergoing treatment. Pregnant and nursing women should also avoid the treatment for safety reasons.

Treatment Process

As with all treatments at my practice in Munich, the procedure for polynucleotide injections into the eye area is carefully structured to ensure the safety of my patients and the best possible results. From the initial consultation and risk assessment through the injection to aftercare, all steps are conducted by me personally and tailored individually.

Initial Consultation and Medical History

Before the actual treatment, a thorough initial consultation takes place. During this time, your skin condition is analyzed, and your medical history is discussed. Together, we determine whether you are suitable for the treatment and if it can meet your expectations. It is important that you provide all relevant information about allergies, previous skin treatments, and your general health.

Skin Cleansing and Disinfection

First, your skin is thoroughly cleansed to remove dirt, oil, and makeup. This is crucial to prevent infections and ensure that the polynucleotide filler performs optimally. The treatment area is then disinfected to minimize the risk of bacterial infections.

Numbing Cream

Based on my experience with polynucleotide injections into the eye area, local anesthesia is generally not necessary. However, if you are particularly sensitive to pain, numbing cream can be applied to the treatment area. This needs to sit for about 20-30 minutes to ensure sufficient anesthesia. During this time, you can relax in my patient lounge.

Polynucleotide Injection

The polynucleotide filler is precisely injected into the skin around the eyes using very fine needles or special cannulas. I personally prefer to use blunt cannulas in the eye area because they significantly reduce the risk of bruising. The injections usually only take a few minutes. After the injection, the eye area is cooled with ice packs to minimize swelling and redness.


For the first 24 hours after treatment, you should touch the eye area as little as possible. Avoid makeup and harsh skincare products that could irritate the skin. It is advisable to use a soothing and moisturizing cream. Also, avoid direct sunlight and protect yourself with a good sunscreen.

Follow-up Check

About 2 weeks after the treatment, we have a follow-up appointment. In favorable cases, this can also be done over the phone or via chat/email. At this appointment, any questions can be addressed and further treatments discussed, if necessary. These follow-up checks are important to ensure that the best possible result is achieved and any potential complications are detected early.

Follow-up Treatments

Depending on your skin condition and desired results, additional sessions may be necessary. The manufacturer of the PDRN filler PhilArt that I use recommends a total of three sessions spaced 2-3 weeks apart. For advanced signs of aging, 4 or 5 sessions may also be considered.

Are There Risks and Side Effects?

Possible Side Effects

As with any cosmetic treatment, there are possible side effects, particularly with injections in the already sensitive eye area. Expected outcomes of polynucleotide injections include redness, swelling, and mild bruising at the injection sites. These side effects are generally mild and disappear within a few days. It is important to treat the injected skin area gently and avoid using harsh skincare products. Furthermore, precautions can be taken before and after the treatment to minimize the risk of unwanted effects. I have compiled these precautions along with behavior tips.

Rare Complications

In rare cases, injections can lead to allergic reactions. These can occur within a few hours or be delayed, often only appearing after several months. Since polynucleotides are derived from salmon DNA, there is a theoretical possibility of the filler being contaminated with residues of fish protein. For patients with such an intolerance, this could lead to more serious reactions. Therefore, it is important to conduct a thorough medical history before treatment and clarify any potential risks.

Additionally, there is a fundamental risk of infection with any treatment involving injections. This risk can be minimized through careful disinfection of the treatment area and professional injection techniques, but it cannot be completely eliminated. Therefore, patients with an existing or not yet fully healed infection in the face should avoid treatment with polynucleotide injections.

What Does Polynucleotide Under Eyes Treatment Cost?


The cost of a polynucleotide filler treatment at my practice in Munich starts at €320. The final price of the treatment is determined individually according to the principles of the medical fee schedule (GOÄ) and depends on the complexity of the case and the amount of filler used. In any case, the price will be firmly agreed upon before the treatment. Therefore, unpleasant surprises afterward are not possible.

No Reimbursement by GKV/PKV

Please note that the costs of an aesthetic treatment with polynucleotides are not reimbursed by statutory or private health insurance.

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Polynucleotides FAQ

How Long Do the Results of a Polynucleotide Treatment Last?

The results of polynucleotide injections depend on individual factors such as skin type, age, and lifestyle. Generally, the positive effects of the treatment can last for several months. Regular maintenance treatments can extend and enhance the results.

Is There Any Downtime After the Treatment?

The treatment with injectable polynucleotides does not involve any downtime. Typically, patients can resume their normal activities immediately.

Is the Treatment Painful?

The treatment is generally well-tolerated, even without anesthesia. If desired, a numbing cream can be applied before the injection to increase comfort.

How Many Sessions Are Required?

I recommend an initial phase of 3-4 treatments spaced 2-3 weeks apart. After that, 2-3 maintenance sessions per year as needed.

Can the Treatment Be Combined with Other Cosmetic Procedures?

Yes, polynucleotide injections can be combined with other cosmetic procedures such as Botox or hyaluronic acid to achieve comprehensive aesthetic results.

About the author:

Dr. med. univ. Eva Maria Strobl is the owner of LIPS and SKIN Aesthetic Medicine practice in Munich. She is a trained specialist in general medicine (MedUni Vienna) and has over 10 years of specialization in non-surgical aesthetic procedures. Dr. Strobl is a member of the German Society for Aesthetic Botulinum Therapy(DGBT), the German Society of Anti-Aging Medicine e.V.(GSAAM) and Network Global Health. She publishes regularly on her blog and on DocCheck.

Sources of this article:

Cavallini et al, Consensus report on the use of PN-HPT™ (polynucleotides highly purified technology) in aesthetic medicine, Link
Croma Pharma, Press release PhilArt Biostimulators, Link

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