Cosmetic BOTOX treatment since the late 1990s
Also in the decades and centuries after Justinus Kerner, the use of BOTOX for medical purposes was far from being on the agenda.
It was only towards the end of the 20th century, that BOTOX was rediscovered for medicine.
Initially it was used exclusively for the treatment of neurological disorders.
BOTOX for cosmetics again came only several years later, and by now has been around for some 20 years.
On the fringes of neurological studies, it was found that in some of the patients marked wrinkles had suddenly disappeared. Without this result having been intended or even only foreseen. Coincidence once again took the lead, as was often the case in the history of medicine.
In 2002, the BOTOX treatment was then officially approved by the American health authority (FDA) for use in wrinkle treatment.
BOTOX – a success story since 2002
The stunning effectiveness of BOTOX in the treatment of facial wrinkles gave rise to a worldwide success story soon thereafter.
BOTOX was quickly considered a new “miracle cure” that conquered aesthetic medicine around the globe.
As always, the celebrities and the “Beautiful People” were the first to jump on the bandwagon and get BOTOX treatments.
BOTOX becomes VISTABEL
The original BOTOX product from the world’s leading manufacturer ALLERGAN is now marketed under the brand VISTABEL in all cosmetic applications. The original name “BOTOX” is reserved for drugs for the treatment of neurological disorders.
At LIPS and SKIN in Munich I exclusively use VISTABEL for cosmetical interventions.
On the one hand, because I appreciate the high quality standard of ALLERGAN and this is the only way to guarantee my Munich patients top results with the lowest possible risks when I inject them with BOTOX.
VISTABLE without animal testing
On the other hand, ALLERGAN is also worth a special appreciation from an ethical point of view.
For example, the company announced years ago that it would soon discontinue all animal testing in the production and control of BOTOX and switch to cell culture-based processes.
This has in the meantime been accomplished. At least in the case of Allergan, no more laboratory animals have to suffer or die for cosmetics. For me, this is an important argument in favour of the company and its VISTABEL product.
BOTOX prices mainly reflect quantity of VISTABEL
At the end of this page I am informing you about my prices for different BOTOX treatments.
Please assume that these are guideline prices. The actual price may differ, mainly as a function of the amount of VISTABEL used in the treatment.
The current price of VISTABEL can easily be researched on the internet. It is (almost) identical throughout Germany and most of Europe.
No imported BOTOX at dumping prices in my practice
From time to time I hear from patients that they have been offered treatment with imported VISTABEL (from countries like Greece) at significantly lower prices.
To these patients, as well as to my readers on this website, I would like to point out that such practices are illegal under German drug law. Practitioners who use illegally imported drugs are liable to prosecution.
For this reason, I also refuse to treat patients who have obtained BOTOX themselves from whatever source outside the official channel.
How much poison is contained in a BOTOX injection?
How much poison is actually absorbed during an aesthetic BOTOX treatment? I am asked this question quite frequently by my patients in Munich. Here is an answer:
The amount of active substance contained in BOTOX injections is measured in so-called Allergan Units (AU).
1 such unit is exactly the dose which is lethal for 50% of a precisely defined population of laboratory mice (so-called “Swiss-Webster mice” of female sex, with a body weight between 18 and 20g).
This 1 unit is accordingly the so-called LD-50 dose, the amount of poison that is the lethale dose for 50% of the population.
If this is extrapolated to a human body weight of about 60kg, the theoretical LD-50 in humans would be about 3000 units.
However, studies with apes have shown that the direct extrapolation from mice to humans is too conservative. It is therefore assumed that the LD-50 in humans is about 5000 units.
5000 units correspond to about 100 commercial vials of BOTOX in cosmetics (50 AU each) or 50 commercial vials (100 AU each) in neurology.
Cosmetic BOTOX treatments usually contain between 15 AU and 100 AU per session. In neurology, maximum doses can also reach 200 AU (migraine) or even 400 AU (spasms).
The distance to the LD-50 dose in cosmetic BOTOX applications is therefore between 50 times and 300 times. In neurology, despite the significantly higher doses, the distance is still 12.5 times.
Thus, statements by laypersons who suspect a direct toxicity of a regular treatment (“if even only slightly overdosed you die”) are certainly wrong and way exaggerated.
On the other hand, however, statements on some medical websites claiming that regular botulinum doses would be “a thousand times” lower than the human LD-50 are also wrong.